effect of coenzyme q10 supplementation on exercise-induced response of inflammatory indicators and blood lactate in male runners

background: heavy exercise cause muscle damage associated with production of inflammatory agents. the purpose of present study was to determine the effect of acute and 14-day coenzyme q10 supplementation on inflammatory, blood lactate and muscle damage in male middle-distance runners.   methods : eighteen male middle-distance runners in a randomized and quasi experimental study were allocated into two equal groups: supplement group (n=9, coenzyme q10: 5mg/kg/day) and placebo group (n=9, dextrose: 5mg/kg/day). after acute (1day) and 14-day supplementation, all subjects were participated in a training like running (competitive 3000 meters). blood samples were obtained in the four phases: one hour before and 18-24 hours after two running protocols. lactate, serum interleukin-6 (il-6), tumor necrosis factor-alpha (tnf-alpha), c-reactive protein (crp) and creatine kinase (ck) were analyzed. repeated anova and bonferunias a post hoc tests were used to determine the changes in four stages. differences between groups were determined by t-test.   results : the results showed that acute and short-term coenzyme q10 supplementation had not significant effect on basal parameters. the acute coenzyme q10 supplementation attenuated only the exercise-induced increase in response of the plasma crp. the short-term (14-day) coenzyme q10 supplementation attenuated the exercise-induced increase in response of the lactate, serum interleukin-6, tumor necrosis factor-alpha, and crp in male middle-distance runners. however, the acute and short-term coenzyme q10 supplementation had not any significant effect on the exercise-induced increase response of total serum creatine kinase.   conclusion : based on the present results, it can be concluded that the 14-day coenzyme q10 supplementation (5mg.kg-1.day-1) is more effective than the acute supplementation to overcome the exercise-induced adverse responses in some oxidative, inflammatory and biochemical parameters. therefore, short-term coenzyme q10 supplementation is recommended to reduce exercise-induced adverse consequences.